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hek 293 t cell line  (ATCC)
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ATCC hek 293 t cell line
Hek 293 T Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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293 t cell line  (Ubigene Biosciences Co Ltd)
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Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of <t>293</t> <t>T</t> cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
293 T Cell Line, supplied by Ubigene Biosciences Co Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human embryonic kidney cell line  (ATCC)
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Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of <t>293</t> <t>T</t> cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Human Embryonic Kidney Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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monolayer cell line  (ATCC)
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Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of <t>293</t> <t>T</t> cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Monolayer Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tumorigenic human cell lines  (ATCC)
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ATCC tumorigenic human cell lines
Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of <t>293</t> <t>T</t> cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Tumorigenic Human Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cell lines human embryonic kidney hek 293 tsa 201 cells atcc crl 1573  (ATCC)
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ATCC cell lines human embryonic kidney hek 293 tsa 201 cells atcc crl 1573
Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of <t>293</t> <t>T</t> cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Cell Lines Human Embryonic Kidney Hek 293 Tsa 201 Cells Atcc Crl 1573, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hela crl 12401 cell lines  (ATCC)
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Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of <t>293</t> <t>T</t> cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Hela Crl 12401 Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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epithelial cell line  (ATCC)
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ATCC epithelial cell line
Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of <t>293</t> <t>T</t> cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Epithelial Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cell line hek293 alk2 r206h a hek293  (ATCC)
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Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of <t>293</t> <t>T</t> cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Cell Line Hek293 Alk2 R206h A Hek293, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cell lines human  (ATCC)
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ATCC cell lines human
Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of <t>293</t> <t>T</t> cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Cell Lines Human, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of 293 T cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Journal: Renal Failure

Article Title: Serum metabolic profiling analysis of Gitelman syndrome using untargeted metabolomics

doi: 10.1080/0886022X.2026.2662094

Figure Lengend Snippet: Metabolomic analysis reveals aberrant lipid metabolism in homozygous GS patients. (A) Comparison of serum total cholesterol (TC) levels between the WT and HOM groups. (B-D) Quantification of total cholesterol (B), free cholesterol (C), and cholesteryl ester (D) levels in lysates of 293 T cells expressing WT or HOM mutant SLC12A3 . (E-G) Quantification of total cholesterol (E), free cholesterol (F), and cholesteryl ester (G) levels in supernatant of 293 T cells expressing WT or HOM mutant SLC12A3 . (H) Heatmap illustrating the differential metabolites in serum samples from the WT and HOM GS groups. Each column represents an independent biological replicate, and each row corresponds to a specific metabolite. Red and blue indicate upregulated and downregulated relative abundances of the metabolites, respectively. (I) KEGG pathway enrichment analysis was performed on the differential metabolites. The analysis revealed that glycerophospholipid metabolism was the most significantly affected pathway. In the bubble plot, the significance of pathway enrichment is indicated by the y-axis position and color scale, while the pathway impact factor is represented by the x-axis position and the size of the bubble. (J, K) ROC curve (J) and statistical analysis (K) for hexanoylglycine. (L, M) ROC curve (L) and statistical analysis (M) for PE(P-18:0/19:1). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Article Snippet: The 293 T cell line with the SLC12A3 c.1262G > T (p.C421F) point mutation was custom-generated by UBIGENE (Contract ID: UBISUM250617ZJ1).

Techniques: Metabolomic, Comparison, Expressing, Mutagenesis